Ezio’s story continues in 1499, where he exits the Vault, confused by what he saw inside. Their mission is to find the Apple of Eden, an important and mysterious artifact that could prevent theimpending disaster that is coming in that same year, believed to be perpetrated by the Templars.
He escapes Rome with his uncle Mario Auditore and arrives at Monteriggioni. Once home, Ezio is comforted by the prospect that his personal vendetta is over and that his days as an Assassin are done; however, Niccolò Machiavelli challenges Ezio’s decision to leave Rodrigo Borgia, now Pope Alexander VI, alive. The following morning, Monteriggioni is besieged by Cesare Borgia, son of Rodrigo. Mario is killed at the hands of Cesare himself, and the Apple lost to Cesare and the Templars. Ezio escapes with his family and travels to Rome, the center of the Templar Order in Italy, once again seeking vengeance against the Borgias. There, he discovers that the Assassins are failing in the fight against corruption. Determined to redeem the Guild, Ezio convinces Machiavelli that he has what it takes to lead while assembling a Brotherhood powerful enough to destroy the Templars and his new arch nemesis, Cesare Borgia.